Document 0120
 DOCN  M9490120
 TI    Acquired immunodeficiency syndrome in the elderly.
 DT    9411
 AU    Adler WH; Nagel JE; Clinical Immunology Section, National Institute on
       Aging,; National Institutes of Health, Baltimore, Maryland.
 SO    Drugs Aging. 1994 May;4(5):410-6. Unique Identifier : AIDSLINE
       MED/94319076
 AB    Recent data from the US show that since 1990 the number of paediatric
       patients with AIDS is decreasing while the number of patients with AIDS
       over age 50 years is increasing. To date, little attention has been
       given to understanding AIDS risk-taking behaviours, clinical
       presentations, and therapeutic needs of middle-aged and older
       HIV-infected individuals. Older HIV-infected individuals deteriorate
       more rapidly than younger patients due to an accelerated loss of CD4+
       helper T cells. Despite recognised age-related physiological differences
       between young and elderly individuals, scant information about drug
       optimisation for the treatment of AIDS in older individuals is
       available. More data need to be collected about this group of AIDS
       patients, and appropriate treatment strategies designed for their
       special needs.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/*EPIDEMIOLOGY/
       ETIOLOGY/*IMMUNOLOGY  Aged  Aging/*IMMUNOLOGY/PHYSIOLOGY  Blood
       Transfusion/ADVERSE EFFECTS  Human  Immunity, Cellular  Prognosis
       Social Isolation  Zidovudine/ADVERSE EFFECTS  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

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